It approved the sustained-release version (Wellbutrin SR) in 1996 and the extended-release version (Wellbutrin XL) in 2003. The FDA reapproved Wellbutrin in 1989 with a lowered daily dose and a warning about the increased risk of seizures. The Food and Drug Administration (FDA) originally approved Wellbutrin as a treatment for depression in 1985. Use of Wellbutrin with Reversible MAOIs Such as Linezolid or Methylene Blue. Wellbutrin may be taken with or without food. Periodically reassess the need for maintenance treatment and the appropriate dose for such treatment. Wellbutrin belongs to the aminoketone class of antidepressants, which are chemically unrelated to the better-known selective-serotonin reuptake inhibitors (SSRIs), such as Prozac, Paxil, or Zoloft. Also be aware that Wellbutrin can cause false-positive urine tests for amphetamines. The warning also extended to Zyban, which contains the same ingredient as Wellbutrin and is made by the same company. It is unknown whether the dose of Wellbutrin needed for maintenance treatment is identical to the dose that provided an initial response. Data from population studies of pregnant women taking Wellbutrin in the first trimester indicated no increased risk of congenital malformations. People who have had a seizure or epilepsy, an eating disorder such as bulimia or anorexia nervosa, or are using or withdrawing from alcohol or certain drugs used to treat anxiety, seizures, and insomnia such as Xanax, Valium, and Ativan, are generally not good candidates for Wellbutrin. Dosing above 300 mg per day may be accomplished using the 75- or 100-mg tablets.
Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term trials. In 2006, Wellbutrin was the first drug the FDA approved for the treatment of seasonal-affective disorder (SAD). Do not start Wellbutrin in a patient who is being treated with a reversible MAOI such as linezolid or intravenous methylene blue. At least 14 days should elapse between discontinuation of an MAOI intended to treat depression and initiation of therapy with Wellbutrin. In many cases, a causal relationship to bupropion treatment is not certain, because depressed mood may be a symptom of nicotine withdrawal. Wellbutrin Tablets should be swallowed whole and not crushed, divided, or chewed. Your doctor also needs to know if you have liver or kidney disease, are taking insulin for diabetes, are taking other antidepressants, or are using a nicotine patch, which can increase the risk of high blood pressure. Wellbutrin (bupropion hydrochloride) is indicated for the treatment of major depressive disorder(MDD), as defined by the Diagnostic and Statistical Manual (DSM ). Switching a Patient to or from a Monoamine Oxidase Inhibitor (MAOI) Antidepressant. However, some of the cases occurred in patients taking bupropion who continued to smoke. In patients of all ages who are started on antidepressant therapy, monitor closely for worsening, and for emergence of suicidal thoughts and behaviors. Under the brand name Zyban, bupropion has also been prescribed to help people quit smoking. A 2010 study in the American Journal of Obstetrics and Gynecology suggested a link between Wellbutrin taken in the first trimester and congenital heart defects but found that more data was needed to confirm a connection. It is generally agreed that acute episodes of depression require several months or longer of antidepressant drug treatment beyond the response in the acute episode. All Consumer Professional Pill ID Interactions News FDA Alerts Approvals Pipeline Clinical Trials Care Notes Encyclopedia Dictionary Natural Products.
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